DatasetDiabetes_hgu133a_collapsed_to_symbols.Diabetes.cls#NGT_versus_DMT
PhenotypeDiabetes.cls#NGT_versus_DMT
Upregulated in classDMT
GeneSetST_T_CELL_SIGNAL_TRANSDUCTION
Enrichment Score (ES)-0.45288643
Normalized Enrichment Score (NES)-1.698733
Nominal p-value0.0080
FDR q-value0.75983596
FWER p-Value0.566
Table: GSEA Results Summary



Fig 1: Enrichment plot: ST_T_CELL_SIGNAL_TRANSDUCTION   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1NFKBIL1NFKBIL1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 15941.7300.0016No
2PAK7PAK7
Entrez,  Source
p21(CDKN1A)-activated kinase 711481.432-0.0016No
3ITPKAITPKA
Entrez,  Source
inositol 1,4,5-trisphosphate 3-kinase A16001.243-0.0023No
4RASGRP3RASGRP3
Entrez,  Source
RAS guanyl releasing protein 3 (calcium and DAG-regulated)17241.1930.0205No
5PAK6PAK6
Entrez,  Source
p21(CDKN1A)-activated kinase 633780.727-0.0845No
6LCKLCK
Entrez,  Source
lymphocyte-specific protein tyrosine kinase37280.652-0.0933No
7NFKB1NFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)42610.547-0.1187No
8CSKCSK
Entrez,  Source
c-src tyrosine kinase52600.351-0.1845No
9FBXW7FBXW7
Entrez,  Source
F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila)60890.194-0.2416No
10ITKITK
Entrez,  Source
IL2-inducible T-cell kinase64280.131-0.2636No
11NFKBIANFKBIA
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha7246-0.021-0.3245No
12NFKBIENFKBIE
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon7602-0.092-0.3488No
13CD3DCD3D
Entrez,  Source
CD3d molecule, delta (CD3-TCR complex)7642-0.098-0.3491No
14SOS1SOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)7737-0.114-0.3531No
15NFAT5NFAT5
Entrez,  Source
nuclear factor of activated T-cells 5, tonicity-responsive7782-0.123-0.3531No
16PLCG1PLCG1
Entrez,  Source
phospholipase C, gamma 17840-0.136-0.3538No
17NCK1NCK1
Entrez,  Source
NCK adaptor protein 19157-0.406-0.4420Yes
18PAK3PAK3
Entrez,  Source
p21 (CDKN1A)-activated kinase 39253-0.428-0.4377Yes
19RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 19350-0.450-0.4328Yes
20GRB2GRB2
Entrez,  Source
growth factor receptor-bound protein 29614-0.507-0.4391Yes
21CBLCBL
Entrez,  Source
Cas-Br-M (murine) ecotropic retroviral transforming sequence9677-0.525-0.4297Yes
22PAK4PAK4
Entrez,  Source
p21(CDKN1A)-activated kinase 49891-0.571-0.4304Yes
23ZAP70ZAP70
Entrez,  Source
zeta-chain (TCR) associated protein kinase 70kDa9902-0.573-0.4158Yes
24VAV1VAV1
Entrez,  Source
vav 1 oncogene9958-0.586-0.4042Yes
25CD28CD28
Entrez,  Source
CD28 molecule10083-0.615-0.3971Yes
26ITPKBITPKB
Entrez,  Source
inositol 1,4,5-trisphosphate 3-kinase B10169-0.634-0.3865Yes
27LATLAT
Entrez,  Source
linker for activation of T cells10380-0.686-0.3839Yes
28NFKB2NFKB2
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100)10468-0.710-0.3714Yes
29GRAP2GRAP2
Entrez,  Source
GRB2-related adaptor protein 210873-0.832-0.3795Yes
30RASGRP1RASGRP1
Entrez,  Source
RAS guanyl releasing protein 1 (calcium and DAG-regulated)11029-0.876-0.3677Yes
31PTPRCPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C11048-0.881-0.3455Yes
32MAPK1MAPK1
Entrez,  Source
mitogen-activated protein kinase 111721-1.127-0.3659Yes
33EPHB2EPHB2
Entrez,  Source
EPH receptor B211875-1.192-0.3454Yes
34SOS2SOS2
Entrez,  Source
son of sevenless homolog 2 (Drosophila)11945-1.223-0.3178Yes
35RASGRP2RASGRP2
Entrez,  Source
RAS guanyl releasing protein 2 (calcium and DAG-regulated)12510-1.532-0.3192Yes
36CTLA4CTLA4
Entrez,  Source
cytotoxic T-lymphocyte-associated protein 412610-1.605-0.2837Yes
37PAK1PAK1
Entrez,  Source
p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast)12644-1.629-0.2425Yes
38LCP2LCP2
Entrez,  Source
lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa)12653-1.640-0.1991Yes
39NFKBIBNFKBIB
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta12821-1.781-0.1640Yes
40DAG1DAG1
Entrez,  Source
dystroglycan 1 (dystrophin-associated glycoprotein 1)13133-2.182-0.1289Yes
41PAK2PAK2
Entrez,  Source
p21 (CDKN1A)-activated kinase 213266-2.613-0.0688Yes
42NFKBIL2NFKBIL2
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 213279-2.7150.0031Yes
Table: GSEA details [plain text format]



Fig 2: ST_T_CELL_SIGNAL_TRANSDUCTION   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: ST_T_CELL_SIGNAL_TRANSDUCTION: Random ES distribution   
Gene set null distribution of ES for ST_T_CELL_SIGNAL_TRANSDUCTION