DatasetDiabetes_hgu133a_collapsed_to_symbols.Diabetes.cls#NGT_versus_DMT
PhenotypeDiabetes.cls#NGT_versus_DMT
Upregulated in classDMT
GeneSetTGF_BETA_SIGNALING_PATHWAY
Enrichment Score (ES)-0.4318179
Normalized Enrichment Score (NES)-1.591629
Nominal p-value0.013487476
FDR q-value0.98279196
FWER p-Value0.828
Table: GSEA Results Summary



Fig 1: Enrichment plot: TGF_BETA_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1TGFBR1TGFBR1
Entrez,  Source
transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa)6901.6740.0068No
2TGFB1TGFB1
Entrez,  Source
transforming growth factor, beta 1 (Camurati-Engelmann disease)9311.5310.0424No
3SKILSKIL
Entrez,  Source
SKI-like14881.2830.0456No
4STAT1STAT1
Entrez,  Source
signal transducer and activator of transcription 1, 91kDa22911.0140.0208No
5FSTFST
Entrez,  Source
follistatin25800.9300.0318No
6FKBP1AFKBP1A
Entrez,  Source
FK506 binding protein 1A, 12kDa26560.9090.0580No
7NFKB1NFKB1
Entrez,  Source
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105)42610.547-0.0435No
8SERPINE1SERPINE1
Entrez,  Source
serpin peptidase inhibitor, clade E (nexin, plasminogen activator inhibitor type 1), member 143620.527-0.0326No
9FOXH1FOXH1
Entrez,  Source
forkhead box H148010.435-0.0503No
10LEF1LEF1
Entrez,  Source
lymphoid enhancer-binding factor 148990.414-0.0431No
11SPP1SPP1
Entrez,  Source
secreted phosphoprotein 1 (osteopontin, bone sialoprotein I, early T-lymphocyte activation 1)53870.322-0.0684No
12JUNJUN
Entrez,  Source
jun oncogene55150.296-0.0676No
13THBS1THBS1
Entrez,  Source
thrombospondin 156290.278-0.0663No
14TGIFTGIF
Entrez,  Source
TGFB-induced factor (TALE family homeobox)63560.144-0.1159No
15EGFEGF
Entrez,  Source
epidermal growth factor (beta-urogastrone)65020.119-0.1227No
16LIFLIF
Entrez,  Source
leukemia inhibitory factor (cholinergic differentiation factor)66250.095-0.1285No
17FOSFOS
Entrez,  Source
v-fos FBJ murine osteosarcoma viral oncogene homolog68980.046-0.1474No
18BMP4BMP4
Entrez,  Source
bone morphogenetic protein 47690-0.107-0.2031No
19RUNX3RUNX3
Entrez,  Source
runt-related transcription factor 38404-0.245-0.2482No
20MAPK9MAPK9
Entrez,  Source
mitogen-activated protein kinase 98576-0.281-0.2512No
21TGFBR2TGFBR2
Entrez,  Source
transforming growth factor, beta receptor II (70/80kDa)8883-0.347-0.2621No
22TNFTNF
Entrez,  Source
tumor necrosis factor (TNF superfamily, member 2)8938-0.359-0.2535No
23IFNGIFNG
Entrez,  Source
interferon, gamma9074-0.388-0.2501No
24TGFBR3TGFBR3
Entrez,  Source
transforming growth factor, beta receptor III (betaglycan, 300kDa)9693-0.528-0.2781No
25ENGENG
Entrez,  Source
endoglin (Osler-Rendu-Weber syndrome 1)11737-1.133-0.3921Yes
26MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 311781-1.155-0.3548Yes
27TFE3TFE3
Entrez,  Source
transcription factor binding to IGHM enhancer 311809-1.165-0.3160Yes
28ZFHX1BZFHX1B
Entrez,  Source
zinc finger homeobox 1b11864-1.188-0.2784Yes
29CTNNB1CTNNB1
Entrez,  Source
catenin (cadherin-associated protein), beta 1, 88kDa12139-1.311-0.2530Yes
30CREBBPCREBBP
Entrez,  Source
CREB binding protein (Rubinstein-Taybi syndrome)12434-1.485-0.2231Yes
31INHBAINHBA
Entrez,  Source
inhibin, beta A (activin A, activin AB alpha polypeptide)12715-1.689-0.1849Yes
32ITGB6ITGB6
Entrez,  Source
integrin, beta 612941-1.887-0.1356Yes
33STAT3STAT3
Entrez,  Source
signal transducer and activator of transcription 3 (acute-phase response factor)13103-2.124-0.0732Yes
34RUNX2RUNX2
Entrez,  Source
runt-related transcription factor 213257-2.5520.0047Yes
Table: GSEA details [plain text format]



Fig 2: TGF_BETA_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: TGF_BETA_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for TGF_BETA_SIGNALING_PATHWAY