DatasetDiabetes_hgu133a_collapsed_to_symbols.Diabetes.cls#NGT_versus_DMT
PhenotypeDiabetes.cls#NGT_versus_DMT
Upregulated in classDMT
GeneSetSIG_BCR_SIGNALING_PATHWAY
Enrichment Score (ES)-0.34774145
Normalized Enrichment Score (NES)-1.3340365
Nominal p-value0.08281574
FDR q-value1.0
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SIG_BCR_SIGNALING_PATHWAY   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1GSK3AGSK3A
Entrez,  Source
glycogen synthase kinase 3 alpha12401.393-0.0467No
2PIK3CDPIK3CD
Entrez,  Source
phosphoinositide-3-kinase, catalytic, delta polypeptide17901.167-0.0489No
3NFATC1NFATC1
Entrez,  Source
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 121301.063-0.0388No
4AKT3AKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)24290.969-0.0287No
5PLCG2PLCG2
Entrez,  Source
phospholipase C, gamma 2 (phosphatidylinositol-specific)26000.924-0.0106No
6AKT1AKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 128690.853-0.0021No
7FLOT1FLOT1
Entrez,  Source
flotillin 129630.8300.0187No
8BADBAD
Entrez,  Source
BCL2-antagonist of cell death32130.7700.0258No
9CSKCSK
Entrez,  Source
c-src tyrosine kinase52600.351-0.1166No
10PPP3CAPPP3CA
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, alpha isoform (calcineurin A alpha)54120.316-0.1173No
11BCL2BCL2
Entrez,  Source
B-cell CLL/lymphoma 256710.268-0.1278No
12PPP1R13BPPP1R13B
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 13B57330.258-0.1237No
13INPP5DINPP5D
Entrez,  Source
inositol polyphosphate-5-phosphatase, 145kDa58890.231-0.1276No
14PPP3CCPPP3CC
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, gamma isoform (calcineurin A gamma)59640.217-0.1259No
15PPP3CBPPP3CB
Entrez,  Source
protein phosphatase 3 (formerly 2B), catalytic subunit, beta isoform (calcineurin A beta)64570.125-0.1588No
16CD19CD19
Entrez,  Source
CD19 molecule66100.098-0.1670No
17BCRBCR
Entrez,  Source
breakpoint cluster region66810.086-0.1694No
18PIK3R1PIK3R1
Entrez,  Source
phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha)7400-0.050-0.2218No
19GSK3BGSK3B
Entrez,  Source
glycogen synthase kinase 3 beta7477-0.065-0.2253No
20FLOT2FLOT2
Entrez,  Source
flotillin 27542-0.078-0.2275No
21SHC1SHC1
Entrez,  Source
SHC (Src homology 2 domain containing) transforming protein 17655-0.101-0.2326No
22SOS1SOS1
Entrez,  Source
son of sevenless homolog 1 (Drosophila)7737-0.114-0.2348No
23LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog8057-0.179-0.2528No
24NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 28197-0.210-0.2563No
25RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 19350-0.450-0.3279No
26GRB2GRB2
Entrez,  Source
growth factor receptor-bound protein 29614-0.507-0.3307Yes
27ITPR2ITPR2
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 29636-0.511-0.3152Yes
28PIK3CAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide9953-0.585-0.3194Yes
29VAV1VAV1
Entrez,  Source
vav 1 oncogene9958-0.586-0.3000Yes
30SYKSYK
Entrez,  Source
spleen tyrosine kinase10054-0.608-0.2868Yes
31ITPR3ITPR3
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 310111-0.621-0.2702Yes
32BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase10443-0.704-0.2715Yes
33MAP4K1MAP4K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase kinase 110666-0.769-0.2625Yes
34BLNKBLNK
Entrez,  Source
B-cell linker10719-0.781-0.2402Yes
35ITPR1ITPR1
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 110812-0.808-0.2200Yes
36PTPRCPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C11048-0.881-0.2082Yes
37MAPK1MAPK1
Entrez,  Source
mitogen-activated protein kinase 111721-1.127-0.2210Yes
38MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 311781-1.155-0.1867Yes
39CR2CR2
Entrez,  Source
complement component (3d/Epstein Barr virus) receptor 211886-1.201-0.1543Yes
40CD81CD81
Entrez,  Source
CD81 molecule11888-1.202-0.1140Yes
41SOS2SOS2
Entrez,  Source
son of sevenless homolog 2 (Drosophila)11945-1.223-0.0773Yes
42AKT2AKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 212561-1.566-0.0710Yes
43PDK1PDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 112651-1.637-0.0229Yes
44DAG1DAG1
Entrez,  Source
dystroglycan 1 (dystrophin-associated glycoprotein 1)13133-2.1820.0141Yes
Table: GSEA details [plain text format]



Fig 2: SIG_BCR_SIGNALING_PATHWAY   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SIG_BCR_SIGNALING_PATHWAY: Random ES distribution   
Gene set null distribution of ES for SIG_BCR_SIGNALING_PATHWAY