DatasetDiabetes_hgu133a_collapsed_to_symbols.Diabetes.cls#NGT_versus_DMT
PhenotypeDiabetes.cls#NGT_versus_DMT
Upregulated in classDMT
GeneSetSIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES
Enrichment Score (ES)-0.3565637
Normalized Enrichment Score (NES)-1.3213662
Nominal p-value0.08935361
FDR q-value1.0
FWER p-Value1.0
Table: GSEA Results Summary



Fig 1: Enrichment plot: SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1PHF11PHF11
Entrez,  Source
PHD finger protein 1110601.471-0.0242No
2SAGSAG
Entrez,  Source
S-antigen; retina and pineal gland (arrestin)12081.4080.0179No
3AKT3AKT3
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)24290.969-0.0374No
4PLCG2PLCG2
Entrez,  Source
phospholipase C, gamma 2 (phosphatidylinositol-specific)26000.924-0.0153No
5AKT1AKT1
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 128690.853-0.0032No
6TECTEC
Entrez,  Source
tec protein tyrosine kinase29340.8370.0236No
7FLOT1FLOT1
Entrez,  Source
flotillin 129630.8300.0528No
8DAPP1DAPP1
Entrez,  Source
dual adaptor of phosphotyrosine and 3-phosphoinositides30120.8200.0801No
9PPP1R13BPPP1R13B
Entrez,  Source
protein phosphatase 1, regulatory (inhibitor) subunit 13B57330.258-0.1149No
10FOXO3AFOXO3A
Entrez,  Source
forkhead box O3A59470.219-0.1226No
11CD19CD19
Entrez,  Source
CD19 molecule66100.098-0.1688No
12BCRBCR
Entrez,  Source
breakpoint cluster region66810.086-0.1708No
13FLOT2FLOT2
Entrez,  Source
flotillin 27542-0.078-0.2326No
14LYNLYN
Entrez,  Source
v-yes-1 Yamaguchi sarcoma viral related oncogene homolog8057-0.179-0.2645No
15NR0B2NR0B2
Entrez,  Source
nuclear receptor subfamily 0, group B, member 28197-0.210-0.2670No
16PTENPTEN
Entrez,  Source
phosphatase and tensin homolog (mutated in multiple advanced cancers 1)8633-0.290-0.2888No
17RPS6KA2RPS6KA2
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 29534-0.489-0.3381Yes
18ITPR2ITPR2
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 29636-0.511-0.3264Yes
19PIK3CAPIK3CA
Entrez,  Source
phosphoinositide-3-kinase, catalytic, alpha polypeptide9953-0.585-0.3281Yes
20VAV1VAV1
Entrez,  Source
vav 1 oncogene9958-0.586-0.3063Yes
21PITX2PITX2
Entrez,  Source
paired-like homeodomain transcription factor 210012-0.597-0.2878Yes
22SYKSYK
Entrez,  Source
spleen tyrosine kinase10054-0.608-0.2679Yes
23ITPR3ITPR3
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 310111-0.621-0.2487Yes
24BTKBTK
Entrez,  Source
Bruton agammaglobulinemia tyrosine kinase10443-0.704-0.2470Yes
25RPS6KB1RPS6KB1
Entrez,  Source
ribosomal protein S6 kinase, 70kDa, polypeptide 110627-0.758-0.2322Yes
26RPS6KA1RPS6KA1
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 110673-0.770-0.2065Yes
27ITPR1ITPR1
Entrez,  Source
inositol 1,4,5-triphosphate receptor, type 110812-0.808-0.1864Yes
28PTPRCPTPRC
Entrez,  Source
protein tyrosine phosphatase, receptor type, C11048-0.881-0.1708Yes
29CDKN2ACDKN2A
Entrez,  Source
cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)11199-0.930-0.1470Yes
30GAB1GAB1
Entrez,  Source
GRB2-associated binding protein 111359-0.988-0.1216Yes
31AKT2AKT2
Entrez,  Source
v-akt murine thymoma viral oncogene homolog 212561-1.566-0.1529Yes
32PSCD3PSCD3
Entrez,  Source
pleckstrin homology, Sec7 and coiled-coil domains 312580-1.578-0.0947Yes
33PDK1PDK1
Entrez,  Source
pyruvate dehydrogenase kinase, isozyme 112651-1.637-0.0381Yes
34RPS6KA3RPS6KA3
Entrez,  Source
ribosomal protein S6 kinase, 90kDa, polypeptide 313205-2.3420.0087Yes
Table: GSEA details [plain text format]



Fig 2: SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES: Random ES distribution   
Gene set null distribution of ES for SIG_PIP3_SIGNALING_IN_B_LYMPHOCYTES