Dataset | Diabetes_hgu133a_collapsed_to_symbols.Diabetes.cls#NGT_versus_DMT |
Phenotype | Diabetes.cls#NGT_versus_DMT |
Upregulated in class | DMT |
GeneSet | ST_T_CELL_SIGNAL_TRANSDUCTION |
Enrichment Score (ES) | -0.45288643 |
Normalized Enrichment Score (NES) | -1.698733 |
Nominal p-value | 0.0080 |
FDR q-value | 0.75983596 |
FWER p-Value | 0.566 |
PROBE | GENE SYMBOL | GENE_TITLE | RANK IN GENE LIST | RANK METRIC SCORE | RUNNING ES | CORE ENRICHMENT | |
---|---|---|---|---|---|---|---|
1 | NFKBIL1 | NFKBIL1 Entrez,  Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1 | 594 | 1.730 | 0.0016 | No |
2 | PAK7 | PAK7 Entrez,  Source | p21(CDKN1A)-activated kinase 7 | 1148 | 1.432 | -0.0016 | No |
3 | ITPKA | ITPKA Entrez,  Source | inositol 1,4,5-trisphosphate 3-kinase A | 1600 | 1.243 | -0.0023 | No |
4 | RASGRP3 | RASGRP3 Entrez,  Source | RAS guanyl releasing protein 3 (calcium and DAG-regulated) | 1724 | 1.193 | 0.0205 | No |
5 | PAK6 | PAK6 Entrez,  Source | p21(CDKN1A)-activated kinase 6 | 3378 | 0.727 | -0.0845 | No |
6 | LCK | LCK Entrez,  Source | lymphocyte-specific protein tyrosine kinase | 3728 | 0.652 | -0.0933 | No |
7 | NFKB1 | NFKB1 Entrez,  Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (p105) | 4261 | 0.547 | -0.1187 | No |
8 | CSK | CSK Entrez,  Source | c-src tyrosine kinase | 5260 | 0.351 | -0.1845 | No |
9 | FBXW7 | FBXW7 Entrez,  Source | F-box and WD-40 domain protein 7 (archipelago homolog, Drosophila) | 6089 | 0.194 | -0.2416 | No |
10 | ITK | ITK Entrez,  Source | IL2-inducible T-cell kinase | 6428 | 0.131 | -0.2636 | No |
11 | NFKBIA | NFKBIA Entrez,  Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha | 7246 | -0.021 | -0.3245 | No |
12 | NFKBIE | NFKBIE Entrez,  Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, epsilon | 7602 | -0.092 | -0.3488 | No |
13 | CD3D | CD3D Entrez,  Source | CD3d molecule, delta (CD3-TCR complex) | 7642 | -0.098 | -0.3491 | No |
14 | SOS1 | SOS1 Entrez,  Source | son of sevenless homolog 1 (Drosophila) | 7737 | -0.114 | -0.3531 | No |
15 | NFAT5 | NFAT5 Entrez,  Source | nuclear factor of activated T-cells 5, tonicity-responsive | 7782 | -0.123 | -0.3531 | No |
16 | PLCG1 | PLCG1 Entrez,  Source | phospholipase C, gamma 1 | 7840 | -0.136 | -0.3538 | No |
17 | NCK1 | NCK1 Entrez,  Source | NCK adaptor protein 1 | 9157 | -0.406 | -0.4420 | Yes |
18 | PAK3 | PAK3 Entrez,  Source | p21 (CDKN1A)-activated kinase 3 | 9253 | -0.428 | -0.4377 | Yes |
19 | RAF1 | RAF1 Entrez,  Source | v-raf-1 murine leukemia viral oncogene homolog 1 | 9350 | -0.450 | -0.4328 | Yes |
20 | GRB2 | GRB2 Entrez,  Source | growth factor receptor-bound protein 2 | 9614 | -0.507 | -0.4391 | Yes |
21 | CBL | CBL Entrez,  Source | Cas-Br-M (murine) ecotropic retroviral transforming sequence | 9677 | -0.525 | -0.4297 | Yes |
22 | PAK4 | PAK4 Entrez,  Source | p21(CDKN1A)-activated kinase 4 | 9891 | -0.571 | -0.4304 | Yes |
23 | ZAP70 | ZAP70 Entrez,  Source | zeta-chain (TCR) associated protein kinase 70kDa | 9902 | -0.573 | -0.4158 | Yes |
24 | VAV1 | VAV1 Entrez,  Source | vav 1 oncogene | 9958 | -0.586 | -0.4042 | Yes |
25 | CD28 | CD28 Entrez,  Source | CD28 molecule | 10083 | -0.615 | -0.3971 | Yes |
26 | ITPKB | ITPKB Entrez,  Source | inositol 1,4,5-trisphosphate 3-kinase B | 10169 | -0.634 | -0.3865 | Yes |
27 | LAT | LAT Entrez,  Source | linker for activation of T cells | 10380 | -0.686 | -0.3839 | Yes |
28 | NFKB2 | NFKB2 Entrez,  Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells 2 (p49/p100) | 10468 | -0.710 | -0.3714 | Yes |
29 | GRAP2 | GRAP2 Entrez,  Source | GRB2-related adaptor protein 2 | 10873 | -0.832 | -0.3795 | Yes |
30 | RASGRP1 | RASGRP1 Entrez,  Source | RAS guanyl releasing protein 1 (calcium and DAG-regulated) | 11029 | -0.876 | -0.3677 | Yes |
31 | PTPRC | PTPRC Entrez,  Source | protein tyrosine phosphatase, receptor type, C | 11048 | -0.881 | -0.3455 | Yes |
32 | MAPK1 | MAPK1 Entrez,  Source | mitogen-activated protein kinase 1 | 11721 | -1.127 | -0.3659 | Yes |
33 | EPHB2 | EPHB2 Entrez,  Source | EPH receptor B2 | 11875 | -1.192 | -0.3454 | Yes |
34 | SOS2 | SOS2 Entrez,  Source | son of sevenless homolog 2 (Drosophila) | 11945 | -1.223 | -0.3178 | Yes |
35 | RASGRP2 | RASGRP2 Entrez,  Source | RAS guanyl releasing protein 2 (calcium and DAG-regulated) | 12510 | -1.532 | -0.3192 | Yes |
36 | CTLA4 | CTLA4 Entrez,  Source | cytotoxic T-lymphocyte-associated protein 4 | 12610 | -1.605 | -0.2837 | Yes |
37 | PAK1 | PAK1 Entrez,  Source | p21/Cdc42/Rac1-activated kinase 1 (STE20 homolog, yeast) | 12644 | -1.629 | -0.2425 | Yes |
38 | LCP2 | LCP2 Entrez,  Source | lymphocyte cytosolic protein 2 (SH2 domain containing leukocyte protein of 76kDa) | 12653 | -1.640 | -0.1991 | Yes |
39 | NFKBIB | NFKBIB Entrez,  Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta | 12821 | -1.781 | -0.1640 | Yes |
40 | DAG1 | DAG1 Entrez,  Source | dystroglycan 1 (dystrophin-associated glycoprotein 1) | 13133 | -2.182 | -0.1289 | Yes |
41 | PAK2 | PAK2 Entrez,  Source | p21 (CDKN1A)-activated kinase 2 | 13266 | -2.613 | -0.0688 | Yes |
42 | NFKBIL2 | NFKBIL2 Entrez,  Source | nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2 | 13279 | -2.715 | 0.0031 | Yes |