DatasetDiabetes_hgu133a_collapsed_to_symbols.Diabetes.cls#NGT_versus_DMT
PhenotypeDiabetes.cls#NGT_versus_DMT
Upregulated in classDMT
GeneSetMAPK_CASCADE
Enrichment Score (ES)-0.4496617
Normalized Enrichment Score (NES)-1.4591694
Nominal p-value0.045081966
FDR q-value1.0
FWER p-Value0.976
Table: GSEA Results Summary



Fig 1: Enrichment plot: MAPK_CASCADE   
Profile of the Running ES Score & Positions of GeneSet Members on the Rank Ordered List

PROBEGENE SYMBOLGENE_TITLERANK IN GENE LISTRANK METRIC SCORERUNNING ESCORE ENRICHMENT
1ELK1ELK1
Entrez,  Source
ELK1, member of ETS oncogene family10771.464-0.0036No
2PLCB3PLCB3
Entrez,  Source
phospholipase C, beta 3 (phosphatidylinositol-specific)14511.3030.0372No
3MAPK10MAPK10
Entrez,  Source
mitogen-activated protein kinase 1029440.835-0.0308No
4MAPK14MAPK14
Entrez,  Source
mitogen-activated protein kinase 1437950.637-0.0611No
5BRAFBRAF
Entrez,  Source
v-raf murine sarcoma viral oncogene homolog B140290.591-0.0474No
6MBPMBP
Entrez,  Source
myelin basic protein53070.341-0.1253No
7JUNJUN
Entrez,  Source
jun oncogene55150.296-0.1252No
8MAP2K4MAP2K4
Entrez,  Source
mitogen-activated protein kinase kinase 459460.219-0.1460No
9MAP3K1MAP3K1
Entrez,  Source
mitogen-activated protein kinase kinase kinase 19304-0.439-0.3752No
10RAF1RAF1
Entrez,  Source
v-raf-1 murine leukemia viral oncogene homolog 19350-0.450-0.3548No
11RRASRRAS
Entrez,  Source
related RAS viral (r-ras) oncogene homolog10613-0.755-0.4098Yes
12MAP2MAP2
Entrez,  Source
microtubule-associated protein 210617-0.756-0.3700Yes
13NRASNRAS
Entrez,  Source
neuroblastoma RAS viral (v-ras) oncogene homolog10755-0.790-0.3386Yes
14MAP2K7MAP2K7
Entrez,  Source
mitogen-activated protein kinase kinase 711508-1.044-0.3400Yes
15MAPK1MAPK1
Entrez,  Source
mitogen-activated protein kinase 111721-1.127-0.2964Yes
16MAPK3MAPK3
Entrez,  Source
mitogen-activated protein kinase 311781-1.155-0.2398Yes
17MAP2K1MAP2K1
Entrez,  Source
mitogen-activated protein kinase kinase 111928-1.218-0.1864Yes
18MAP2K6MAP2K6
Entrez,  Source
mitogen-activated protein kinase kinase 612382-1.450-0.1438Yes
19MAP3K3MAP3K3
Entrez,  Source
mitogen-activated protein kinase kinase kinase 312798-1.758-0.0821Yes
20MAP3K2MAP3K2
Entrez,  Source
mitogen-activated protein kinase kinase kinase 213191-2.2950.0097Yes
Table: GSEA details [plain text format]



Fig 2: MAPK_CASCADE   
Blue-Pink O' Gram in the Space of the Analyzed GeneSet



Fig 3: MAPK_CASCADE: Random ES distribution   
Gene set null distribution of ES for MAPK_CASCADE